1. Recommended Dosage
- Dose: 400 mg taken by mouth twice daily, approximately every 12 hours.
- Schedule: Take medication for 4 consecutive days, then take 3 days off.
- With or without food: Either is acceptable.
If you miss a dose:
- You may take it within 4 hours of the scheduled time.
- If more than 4 hours have passed, skip that dose and take your next dose at the regular time.
- Do not take two doses to make up for the missed one.
2. Important Precautions & Monitoring
A. Blood Sugar (High Glucose)
- Routine monitoring of fasting blood glucose and HbA1c before and during treatment is essential.
- If you have diabetes or are at high risk, it’s important to monitor blood sugars at home and adjust your treatment (for example, diabetes medication) as needed.
B. Diarrhea Management
- At the first sign of loose stool, start anti‑diarrhea treatment such as loperamide and increase your fluid intake.
- If diarrhea persists, seek medical advice to check electrolyte levels (salts in the blood) and prevent complications.
C. Skin Side Effects
- If you notice a rash (or redness or blisters), contact a dermatologist or your healthcare provider early.
- For more severe skin reactions, treatment may need to be paused and a short course of corticosteroids may be recommended.
D. Effects on Pregnancy (Embryo‑Fetal Toxicity)
- Women of childbearing potential must use effective contraception during treatment and for 1 month after stopping the drug.
- Men must use contraception during treatment and for 4 months after stopping the drug.
Summary Table
| Area | What to Do |
|---|---|
| Dosage | 400 mg twice daily → 4 days on, 3 days off |
| Missed Dose | Take within 4 hours or skip; never double up |
| Blood Sugar | Monitor fasting glucose & HbA1c; home monitoring if at high risk |
| Diarrhea | Start treatment immediately upon first loose stool; drink plenty of fluids |
| Skin Reactions | Report rash/redness early; severe cases require medical assessment |
| Pregnancy Precautions | Use contraception: women (during + 1 month after), men (during + 4 months) |
Contact & Support
If you have any questions or concerns about your treatment with Capivasertib—such as side effects, missed doses, or managing concurrent health conditions—get in touch with your healthcare team promptly. They are here to help you use this medication safely and effectively.
