LuciNfig (infigratinib) is a prescription medicine taken by mouth in capsule form. Your doctor will provide a personalized dosing plan, but the information below can help you understand how LuciNfig is typically used, what to expect, and how to take it safely.
1. Dosage for Bone Growth Conditions (e.g., Achondroplasia)
For children and adolescents with achondroplasia or hypochondroplasia (a milder form):
- Typical dose: ~0.25 mg per kg of body weight per day
- Frequency: Once daily
- Capsule options: 25 mg or 100 mg capsules depending on weight
- Timing: Same time every day, preferably in the morning
- How to take: On an empty stomach
This approach has shown steady growth improvements with minimal side effects in clinical studies.
2. Dosage for Cancer Treatment (e.g., Cholangiocarcinoma)
For adults with FGFR-related cancers:
- Recommended dose: 100 mg once daily
- Cycle: 21 days on treatment, followed by 7 days off in each 28-day cycle (fda.gov, bridgebio.com)
- Form options: One 100 mg capsule daily or four 25 mg capsules
This cycle helps balance effectiveness with recovery time.
3. Important Instructions for Taking LuciNfig
To ensure LuciNfig works properly:
- Take on an empty stomach
- At least 1 hour before or 2 hours after a meal
- Only water—no snacks, juices, or milk
- Swallow capsules whole
- Do not crush, open, or chew
- Use a full glass of water
- Stay consistent
- Take it at the same time each day
- Set reminders or use a medication app
4. Dose Adjustments Based on Tolerance
If side effects occur, your doctor might adjust the dose:
| Dose Level | How It’s Taken |
|---|---|
| 100 mg | One 100 mg capsule daily |
| 75 mg | Three 25 mg capsules daily |
| 50 mg | Two 25 mg capsules daily |
This offers flexible, patient-specific treatment.
5. Adjustments for Kidney or Liver Conditions
Doctors may modify dosing if you have:
- Mild to moderate kidney impairment: 100 mg daily, 21 days on/7 days off
- Mild liver impairment: Same as above
- Moderate liver impairment: Reduce to 75 mg daily, same cycle
6. What If You Miss a Dose
- < 12 hours late? Take it as soon as you remember
- > 12 hours late? Skip it and resume next day—do not double up
7. Drug Interactions and Precautions
To avoid complications:
- Avoid antacids, H₂ blockers, and PPIs near dosing time:
- Antacids: 2 hours before/after dose
- H₂ blockers: 2 hours before or 10 hours after dose
- Avoid grapefruit and similar products —they can increase drug levels
- Use effective contraception, as LuciNfig may cause birth defects
8. Capsule Details
LuciNfig capsules are color-coded for easy identification:
- 100 mg: Brown cap, yellow body
- 25 mg: Smaller capsule
Your pharmacy will provide the right capsule combination per your prescription.
