QTc Interval Prolongation:
- Monitor electrocardiograms (ECGs) and electrolyte levels regularly.
- Correct hypokalemia and hypomagnesemia before and during treatment.
- If QTc prolongation occurs, interrupt, reduce, or permanently discontinue LuciRevu as clinically indicated.
Embryo-Fetal Toxicity:
LuciRevu can cause fetal harm when administered during pregnancy.Advise females of reproductive potential and males with female partners of reproductive potential about the potential risk to a fetus.
Recommend use of effective contraception during treatment and for the appropriate period after the last dose.
Drug Interactions
A. Strong CYP3A4 Inhibitors
These drugs can raise LuciRevu levels in the blood, increasing the risk of side effects.
What to do: If combined, your doctor may need to reduce your LuciRevu dose.
Examples include:
- Ketoconazole
- Itraconazole
- Clarithromycin
- Ritonavir
B. Strong or Moderate CYP3A4 Inducers
These drugs can lower LuciRevu levels, reducing how well it works.
Avoid using them with LuciRevu.
Examples include:
- Rifampin
- Carbamazepine
- Phenytoin
- St. John’s Wort
C. QTc-Prolonging Drugs
Using LuciRevu with other drugs that affect heart rhythm increases the risk of heart problems.
Avoid if possible. If combination is necessary, your doctor will closely monitor ECGs.
Examples include:
- Amiodarone
- Sotalol
- Ciprofloxacin
- Ondansetron
